Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Dimethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638204 | 0.92 | TSHR (0.84) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| Methylhydrazine SCHEMBL28282625 | 0.91 | TSHR (0.73) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| Sulfuric Acid SCHEMBL6731449 | 0.90 | TSHR (0.80) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| Methyl Alcohol SCHEMBL2996522 | 0.90 | TSHR (0.89) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| Ethane SCHEMBL4196548 | 0.90 | TSHR (0.89) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| SCHEMBL3409457 | 0.89 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| SCHEMBL30307036 | 0.89 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| SCHEMBL597672 | 0.89 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| Benzene SCHEMBL9751882 | 0.89 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6CA1 | |
| SCHEMBL2509 | 0.89 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120372-A1 | SALTS OF A HETEROCYCLIC COMPOUND AND CRYSTALLINE FORMS, PROCESSES FOR PREPARING, THERAPEUTIC USES, AND PHARMACEUTICAL COMPOSITIONS THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2022-06-09 | — | — | WO | claimed |
| CN-113784755-B | Salts of isochroman-based compounds, crystalline forms thereof, methods of preparation, therapeutic uses and pharmaceutical compositions | 赛诺维信制药公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117255836-A | Coated article, method of making coated article, and method of making composition | 康宁公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-104926729-B | A kind of method for synthesizing ethiprole | 上海泰禾国际贸易有限公司 | 2018-01-19 | — | — | CN | disclosed |
| CN-101752098-B | Method of manufacturing solid electrolytic capacitor | SANYO ELECTRIC CO | 2012-11-14 | — | — | CN | disclosed |
| CN-101752098-A | Method of manufacturing solid electrolytic capacitor | SANYO ELECTRIC CO | 2010-06-23 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| EP-0736574-B1 | Thermoplastic resin composition comprising carbonate and acrylic resin | GEN ELECTRIC (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-6103827-A | A TRANSPARENT THERMOPLASTIC RESIN BLENDS | GENERAL ELECTRIC COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| US-5888308-A | Process for removing residue from screening masks with alkaline solution | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1999-03-30 | — | — | US | disclosed |
| US-5883194-A | RADIATION TRANSPARENT THERMOPLASTIC RESINS OF CARBONATE AND ESTER BLENDS WITH ACRYLATE RESINS AND CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| CN-1141935-A | Thermoplastic resin composition | GEN ELECTRICS CORP (US) | 1997-02-05 | — | — | CN | disclosed |
| EP-0736574-A2 | Thermoplastic resin composition comprising carbonate and acrylic resin | GENERAL ELECTRIC COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5053494-A | FIBER REACTIVE POLYAZO DYE HAVING TWO VINYLSULFONE TYPE REACTIVE GROUPS THROUGH TRIAZINYL BRIDGING GROUP | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0266774-B1 | POLYAZO COMPOUND HAVING TWO VINYLSULFONE TYPE FIBER REACTIVE GROUPS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| EP-0266774-A1 | Polyazo compound having two vinylsulfone type fiber reactive groups | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-05-11 | — | — | EP | disclosed |