Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL587299 | 0.95 | DPP4 (0.36) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL580849 | 0.95 | P2RX7 (0.35) | NPSR1P2RX7HPGDHSD17B10 | |
| SCHEMBL586626 | 0.91 | OPRK1 (0.37) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL586775 | 0.89 | MAPT (0.36) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL587515 | 0.89 | FFAR2 (0.39) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL580874 | 0.86 | CHRNB4 (0.35) | OPRK1 | |
| SCHEMBL586973 | 0.86 | OPRK1 (0.39) | ALDH1A1MAPTMEN1KMT2ADPP4 | |
| SCHEMBL587349 | 0.85 | MMP1 (0.41) | MMP1ADAM17SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL587099 | 0.84 | ALDH1A1 (0.34) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL581842 | 0.84 | MAPT (0.39) | ALDH1A1MAPTNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |