Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 3/20 | 0.40 |
| ▸ | GHSR | Q92847 | 3/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | CASP7 | P55210 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877102 | 0.90 | ALDH1A1 (0.40) | AVPR1BGHSRCYP2D6KCNH2CYP3A4 | |
| SCHEMBL7486076 | 0.88 | CYP2D6 (0.40) | AVPR1BGHSRCYP2D6KCNH2CYP3A4 | |
| SCHEMBL5877833 | 0.86 | ABCC1 (0.45) | MAPK1MEN1KMT2AADORA1ALDH1A1 | |
| SCHEMBL5877056 | 0.86 | CRHR1 (0.43) | GHSRF11CYP2D6KCNH2HRH3 | |
| SCHEMBL5877978 | 0.83 | AVPR1B (0.49) | AVPR1BGHSRF11CYP2D6KCNH2 | |
| SCHEMBL7486775 | 0.83 | EGFR (0.41) | GHSRCYP2D6KCNH2CYP3A4MAPK1 | |
| SCHEMBL5877936 | 0.83 | CRHR1 (0.41) | GHSRF11CYP2D6KCNH2HRH3 | |
| SCHEMBL5876981 | 0.82 | F11 (0.52) | AVPR1BGHSRF11CYP2D6KCNH2 | |
| SCHEMBL5877453 | 0.82 | CRHR1 (0.42) | GHSRTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL5877446 | 0.81 | CRHR1 (0.41) | GHSRF11CYP2D6KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | claimed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | claimed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | claimed |