Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 16/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877712 | 0.95 | AVPR1B (0.51) | AVPR1B | |
| SCHEMBL5877695 | 0.94 | AVPR1B (0.46) | AVPR1BLMNAMAPTHTTNPSR1 | |
| SCHEMBL5877811 | 0.92 | ABCC1 (0.46) | AVPR1BABCC1 | |
| SCHEMBL5878217 | 0.91 | POLB (0.46) | AVPR1B | |
| SCHEMBL5877963 | 0.90 | ALDH1A1 (0.47) | AVPR1BLMNAMAPTNPSR1ABCC1 | |
| SCHEMBL5877265 | 0.89 | ABCC1 (0.44) | AVPR1BLMNAMAPTABCC1 | |
| SCHEMBL5877978 | 0.89 | AVPR1B (0.49) | AVPR1BABCC1 | |
| SCHEMBL5877626 | 0.89 | ABCC1 (0.52) | AVPR1BABCC1 | |
| SCHEMBL5877563 | 0.88 | F11 (0.50) | AVPR1BLMNAMAPTNPSR1ABCC1 | |
| SCHEMBL5877946 | 0.88 | AVPR1A (0.48) | AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |