Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877637 | 0.94 | F11 (0.49) | ABCC1F11KCNH2ADRA1AHRH3 | |
| SCHEMBL5877963 | 0.94 | ALDH1A1 (0.47) | ABCC1F11ALDH1A1MAPTHPGD | |
| SCHEMBL5877392 | 0.91 | CYP2D6 (0.46) | ABCC1F11KCNH2ADRA1AHRH3 | |
| SCHEMBL5877228 | 0.90 | ABCC1 (0.55) | ABCC1ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL5877563 | 0.90 | F11 (0.50) | ABCC1F11ALDH1A1MAPTHPGD | |
| SCHEMBL5876953 | 0.90 | ABCC1 (0.50) | ABCC1ALDH1A1SMN1; SMN2KCNH2CYP2D6 | |
| SCHEMBL5877862 | 0.89 | AVPR1B (0.46) | ABCC1MAPTLMNAAVPR1B | |
| SCHEMBL5877732 | 0.89 | ABCC1 (0.52) | ABCC1ALDH1A1KCNH2CYP2D6HTR2C | |
| SCHEMBL5876985 | 0.88 | CRHR1 (0.44) | ABCC1F11ALDH1A1MAPTHPGD | |
| SCHEMBL5876981 | 0.88 | F11 (0.52) | ABCC1F11ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |