Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14698771 | 0.79 | KDM4E (0.49) | CNR2CNR1KDM4EALDH1A1STAT3 | |
| SCHEMBL7401300 | 0.73 | KDM4E (0.42) | CNR2CNR1PIM1KDM4EALDH1A1 | |
| SCHEMBL4971065 | 0.72 | CDK4 (0.40) | CNR2CNR1KDM4ELMNAALDH1A1 | |
| SCHEMBL2230387 | 0.69 | KLK5 (0.49) | CNR2KDM4ELMNAALDH1A1RAB9A | |
| SCHEMBL17306424 | 0.66 | ALDH1A1 (0.59) | PIM1KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6929061 | 0.66 | TSHR (0.46) | KDM4ELMNAALDH1A1HSD17B10NCEH1 | |
| SCHEMBL6556918 | 0.66 | PIM1 (0.43) | CNR2CNR1PIM1LMNAALDH1A1 | |
| SCHEMBL28704783 | 0.66 | TYMS (0.44) | PIM1KDM4EALDH1A1HSD17B10HIF1A | |
| SCHEMBL28059710 | 0.64 | KMT2A (0.48) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL367040 | 0.64 | HSD17B10 (0.61) | KDM4EALDH1A1HSD17B10RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258168-B2 | 2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof | SANOFI (FR) | 2012-09-04 | — | — | US | disclosed |
| US-8258168-B2 | 2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof | SANOFI (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20120108584-A1 | 2H OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2012-05-03 | — | — | US | disclosed |
| US-8114899-B2 | 2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-02-14 | — | — | US | disclosed |
| US-8114899-B2 | 2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-02-14 | — | — | US | disclosed |
| CN-100577648-C | Carbamate derivatives of 2H-or 3H-benzo [ e ] indazol-1-yl, preparation thereof and therapeutic use thereof | SANOFI AVENTIS | 2010-01-06 | — | — | CN | disclosed |
| US-20090143380-A1 | 2H- OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-06-04 | — | — | US | disclosed |
| US-7501449-B2 | 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-03-10 | — | — | US | disclosed |
| US-7501449-B2 | 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-03-10 | — | — | US | disclosed |
| US-20070105932-A1 | 2H-or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | disclosed |
| US-20070105932-A1 | 2H-or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | disclosed |
| CN-1930131-A | Carbamate derivatives of 2H-or 3H-benzo [ e ] indazol-1-yl, preparation thereof and therapeutic use thereof | SANOFI AVENTIS (FR) | 2007-03-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105932-A1 | 2H-or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | GLS2, GLS, CYP11B2 | CNR2 36/4885CNR1 86/4885PIM1 1258/4885 |
| US-20090143380-A1 | 2H- OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | GLS2, GLS, SDHA | CNR2 31/4885CNR1 76/4885PIM1 1372/4885 |
| US-20120108584-A1 | 2H OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | GLS2, GLS, SDHA | CNR2 18/4885CNR1 63/4885PIM1 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.