Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.90 |
| ▸ | MMP13 | P45452 | 3/20 | 0.90 |
| ▸ | MMP7 | P09237 | 1/20 | 0.69 |
| ▸ | CXCR3 | P49682 | 7/20 | 0.45 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TGM1 | P22735 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5883446 | 1.00 | CYP3A4 (0.90) | CYP3A4MMP13MMP7CXCR3MMP14 | |
| SCHEMBL5883925 | 0.95 | CYP3A4 (1.00) | CYP3A4MMP13MMP7CXCR3MMP14 | |
| SCHEMBL14259982 | 0.95 | CYP3A4 (1.00) | CYP3A4MMP13MMP7CXCR3MMP14 | |
| SCHEMBL14252797 | 0.91 | CYP3A4 (0.78) | CYP3A4MMP13MMP7CXCR3MMP14 | |
| SCHEMBL3940017 | 0.88 | CYP3A4 (0.72) | CYP3A4MMP13MMP7MMP14ADAMTS4 | |
| SCHEMBL13923643 | 0.88 | CYP3A4 (0.72) | CYP3A4MMP13MMP7MMP14ADAMTS4 | |
| SCHEMBL5883710 | 0.87 | MMP7 (0.72) | CYP3A4MMP13MMP7MMP14ADAMTS4 | |
| SCHEMBL5883961 | 0.87 | MMP7 (0.72) | CYP3A4MMP13MMP7MMP14ADAMTS4 | |
| SCHEMBL5883099 | 0.87 | MMP7 (0.72) | CYP3A4MMP13MMP7MMP14ADAMTS4 | |
| SCHEMBL5916481 | 0.87 | CYP3A4 (0.83) | CYP3A4MMP13MMP7CXCR3MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060287338-A1 | Metalloproteinase inhibitor compounds | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | claimed |
| US-20040176386-A1 | Compounds | ASTRAZENECA AB (SE) | 2004-09-09 | — | — | US | claimed |
| US-6734183-B2 | USEFUL AS METALLOPROTEINASE INHIBITOR; PIPERAZINO-SULFONAMIDE OR PIPERIDINO-SULFONAMIDE COMPOUND | ASTRAZENECA AB (SE) | 2004-05-11 | — | — | US | claimed |
| US-20020022628-A1 | Compounds | ASTRAZENECA AB (SE) | 2002-02-21 | — | — | US | claimed |
| US-20060287338-A1 | Metalloproteinase inhibitor compounds | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | disclosed |
| US-7122551-B2 | Metalloproteinase inhibitor compounds | ASTRAZENECA AB (SE) | 2006-10-17 | — | — | US | disclosed |
| US-20040176386-A1 | Compounds | ASTRAZENECA AB (SE) | 2004-09-09 | — | — | US | disclosed |
| US-6734183-B2 | USEFUL AS METALLOPROTEINASE INHIBITOR; PIPERAZINO-SULFONAMIDE OR PIPERIDINO-SULFONAMIDE COMPOUND | ASTRAZENECA AB (SE) | 2004-05-11 | — | — | US | disclosed |
| US-20020022628-A1 | Compounds | ASTRAZENECA AB (SE) | 2002-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022628-A1 | Compounds | MMP13, MMP11, MMP3 | CYP3A4 578/4885MMP13 1/4885MMP7 16/4885 |
| US-20060287338-A1 | Metalloproteinase inhibitor compounds | TIMP3, MMP2, MMP13 | CYP3A4 1526/4885MMP13 3/4885MMP7 18/4885 |
| US-20040176386-A1 | Compounds | MMP13, MMP11, MMP3 | CYP3A4 578/4885MMP13 1/4885MMP7 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.