Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TPO | P07202 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LPO | P22079 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28652276 | 0.78 | HIF1A (0.38) | HIF1AEPAS1MPOTPOTSHR | |
| SCHEMBL588074 | 0.78 | HIF1A (0.38) | HIF1AEPAS1MPOTPOTSHR | |
| SCHEMBL15705441 | 0.74 | HIF1A (0.38) | HIF1AEPAS1MPOTPOTSHR | |
| SCHEMBL2009527 | 0.69 | — | — | |
| SCHEMBL11057529 | 0.68 | HIF1A (0.50) | HIF1AEPAS1TSHR | |
| SCHEMBL3420960 | 0.65 | HIF1A (0.36) | HIF1AEPAS1MPOTPOTSHR | |
| SCHEMBL15971797 | 0.63 | HCAR2 (0.34) | HIF1AEPAS1MPOTPOTSHR | |
| SCHEMBL587729 | 0.63 | HIF1A (0.73) | HIF1AEPAS1MPOTPOTSHR | |
| SCHEMBL28091378 | 0.63 | ALDH1A1 (0.46) | ALDH1A3ALDH1A1ALDH3A1LMNA | |
| SCHEMBL7005086 | 0.60 | LMNA (0.37) | ALDH1A3ALDH1A1ALDH3A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753746-B8 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM SPA (IT) | 2012-02-15 | — | — | EP | disclosed |
| EP-1753746-B1 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM SPA (IT) | 2011-07-27 | — | — | EP | disclosed |
| US-7906501-B2 | Pyrrole derivatives with angiotensin II antagonist activity | ROTTAPHARM S.P.A. (IT) | 2011-03-15 | — | — | US | disclosed |
| US-20070244170-A1 | Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity | ROTTAPHARM BIOTECH S.R.L. (IT) | 2007-10-18 | — | — | US | disclosed |
| EP-1753746-A2 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM S.P.A. (IT) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005105789-A2 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM S.P.A. (IT) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244170-A1 | Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity | AGTR2, AGTR1, REN | HIF1A 1072/4885EPAS1 1395/4885MPO 1813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.