Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | SDHB | P21912 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887580 | 0.88 | ESR2 (0.35) | HSD17B1HSD17B2PTPN5PDK2PTGS2 | |
| SCHEMBL5887499 | 0.86 | ALKBH3 (0.41) | ARL3MBTL1HSD17B1HSD17B2 | |
| SCHEMBL5887311 | 0.79 | KMT2A (0.36) | MEN1KMT2AL3MBTL1HSD17B1HSD17B2 | |
| SCHEMBL5887353 | 0.77 | MEN1 (0.35) | MEN1KMT2AL3MBTL1HSD17B2FYN | |
| SCHEMBL5887498 | 0.76 | HSD11B1 (0.34) | ARMEN1KMT2APDK2 | |
| SCHEMBL5887236 | 0.70 | ESR2 (0.35) | PTPN5PDK2PTGS2 | |
| SCHEMBL5887199 | 0.68 | KMT2A (0.35) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL5887285 | 0.67 | ALKBH3 (0.44) | MEN1KMT2AL3MBTL1CLK4NISCH | |
| SCHEMBL6047649 | 0.66 | L3MBTL1 (0.38) | MEN1KMT2AL3MBTL1NISCHCHRNB4 | |
| SCHEMBL5887245 | 0.66 | AR (0.31) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |