Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887580 | 0.79 | ESR2 (0.35) | PDK2 | |
| SCHEMBL5887426 | 0.78 | MEN1 (0.34) | MEN1POLBKMT2ACYP2D6CYP2C9 | |
| SCHEMBL5887149 | 0.76 | AR (0.38) | MEN1KMT2AARPDK2 | |
| SCHEMBL5887499 | 0.72 | ALKBH3 (0.41) | ARCYP2C9HPGDALOX15CYP2C19 | |
| SCHEMBL5887625 | 0.68 | HSP90AA1 (0.36) | MEN1KMT2AHSD17B10CYP2A6 | |
| SCHEMBL1045000 | 0.66 | CYP2A6 (0.65) | HSD11B1MEN1POLBKMT2AHPGD | |
| SCHEMBL5887436 | 0.65 | CYP2A6 (0.36) | HSD11B1MEN1POLBKMT2ACYP2D6 | |
| SCHEMBL5887191 | 0.65 | MEN1 (0.37) | MEN1POLBKMT2A | |
| SCHEMBL5887347 | 0.64 | MEN1 (0.35) | MEN1POLBKMT2A | |
| SCHEMBL6047646 | 0.63 | CYP2D6 (0.32) | CYP2D6CYP2C9HPGDALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |