Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887581 | 0.90 | KLKB1 (0.38) | PPARGHDAC1NAMPTLMNAKLKB1 | |
| SCHEMBL5887234 | 0.90 | HDAC1 (0.42) | HDAC1RXFP1ALDH1A1TP53LMNA | |
| SCHEMBL5887131 | 0.87 | HDAC1 (0.40) | HDAC1RXFP1ALDH1A1TP53LMNA | |
| SCHEMBL5887359 | 0.86 | MAOA (0.41) | PPARGHDAC1LMNA | |
| SCHEMBL5887284 | 0.85 | MAPT (0.40) | HDAC1RXFP1ALDH1A1TP53LMNA | |
| SCHEMBL5887537 | 0.85 | ALDH1A1 (0.41) | HDAC1ALDH1A1TP53LMNAMEN1 | |
| SCHEMBL5886769 | 0.84 | PPARG (0.43) | PPARGHDAC1RXFP1ALDH1A1NAMPT | |
| SCHEMBL5887193 | 0.84 | SMN1; SMN2 (0.43) | PPARGRXFP1ALDH1A1NAMPTTP53 | |
| SCHEMBL5887463 | 0.83 | LMNA (0.45) | HDAC1TP53LMNAMEN1KMT2A | |
| SCHEMBL5887531 | 0.82 | HDAC1 (0.42) | HDAC1JAK2JAK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019002-B2 | Substituted on 8th position with benzoic acid, ester or amide groups; anticancer agents | PHARMACIA & UPJOHN, S.P.A. (IT) | 2006-03-28 | — | — | US | claimed |
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | PHARMACIA ITALIA S.P.A. | 2004-01-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | TERT, TERF2, TERF2IP | PPARG 3749/4885HDAC1 1062/4885RXFP1 4707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.