Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159163 | 0.83 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL6524477 | 0.83 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| Hydrochloric Acid SCHEMBL28389120 | 0.81 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL11632322 | 0.80 | RAB9A (0.78) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL28879898 | 0.80 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL4019998 | 0.79 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL6307134 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL1860288 | 0.79 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2IDO1CA12 | |
| SCHEMBL7858 | 0.79 | KDM4E (0.69) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL28802667 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2IDO1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106957279-A | (S)-N- (1- phenethyls) thioacetyl amine compounds and its Pharmaceutical composition and its application | 复旦大学 | 2017-07-18 | — | — | CN | claimed |
| US-20230321073-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION | Response IP Holding Company, LLC (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230321073-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION | Response IP Holding Company, LLC (US) | 2023-10-12 | — | — | US | disclosed |
| CN-106957279-B | (S) -N- (1-phenethyl) thioacetamide compound, medicinal composition and application thereof | 复旦大学 | 2021-01-22 | — | — | CN | disclosed |
| CN-106957279-B | (S) -N- (1-phenethyl) thioacetamide compound, medicinal composition and application thereof | 复旦大学 | 2021-01-22 | — | — | CN | disclosed |
| CN-109796387-A | The preparation method of thio trifluoroacetyl amine compounds | 温州大学 | 2019-05-24 | — | — | CN | disclosed |
| CN-106957279-A | (S)-N- (1- phenethyls) thioacetyl amine compounds and its Pharmaceutical composition and its application | 复旦大学 | 2017-07-18 | — | — | CN | disclosed |
| CN-106957279-A | (S)-N- (1- phenethyls) thioacetyl amine compounds and its Pharmaceutical composition and its application | 复旦大学 | 2017-07-18 | — | — | CN | disclosed |
| CN-106957279-A | (S)-N- (1- phenethyls) thioacetyl amine compounds and its Pharmaceutical composition and its application | 复旦大学 | 2017-07-18 | — | — | CN | disclosed |
| US-9656960-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-8980915-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980915-B2 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| EP-1877369-B1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND APO-B SECRETION | SURFACE LOGIX INC (US) | 2013-07-10 | — | — | EP | disclosed |
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |
| US-20070027183-A1 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027183-A1 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | SURFACE LOGIX, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-7105545-B2 | N-p-propargyloxyphenethyl-thioacetic acid amides | SYNGENTA CROP PROTECTION, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20040127739-A1 | Novel n-p-propargyloxyphenethyl-thioacetic acid amides | SYNGENTA CROP PROTECTION, INC. | 2004-07-01 | — | — | US | disclosed |
| EP-1373197-A2 | NOVEL N-P-PROPARGYLOXYPHENETHYL-THIOACETIC ACID AMIDES | Syngenta Participations AG (CH) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081437-A2 | NOVEL N-P-PROPARGYLOXYPHENETHYL-THIOACETIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321073-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION | LIPC, CPT1A, CETP | NPC1 86/4885RAB9A 2919/4885SMN1; SMN2 2745/4885 |
| US-20040127739-A1 | Novel n-p-propargyloxyphenethyl-thioacetic acid amides | O60361, OGA, GRHPR | NPC1 1184/4885RAB9A 1986/4885SMN1; SMN2 4842/4885 |
| US-20070027183-A1 | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion | APOB, CETP, MTTP | NPC1 22/4885RAB9A 3405/4885SMN1; SMN2 4606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.