Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28614872 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL5152358 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL5894504 | 0.70 | ALDH1A1 (0.41) | ALDH1A1MAPTCYP1A2CA12CA9 | |
| SCHEMBL28921608 | 0.68 | ALDH1A1 (0.35) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL5894552 | 0.68 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4ELMNANPC1 | |
| SCHEMBL996754 | 0.68 | CA12 (0.41) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL18095030 | 0.68 | MAPT (0.38) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL8821267 | 0.68 | EGFR (0.40) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL22144248 | 0.67 | NCF1 (0.36) | ALDH1A1MAPTACHENCF1CYP1A2 | |
| SCHEMBL22124480 | 0.66 | RXFP1 (0.40) | ALDH1A1MAPTHPGDCYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119638634-A | Cinnoline-2-oxide compound, preparation method and application thereof | 上海赛默罗生物科技有限公司 | 2025-03-18 | — | — | CN | claimed |
| EP-3849984-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-C] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | Suzhou Zanrong Pharma Limited (CN) | 2021-07-21 | — | — | EP | claimed |
| WO-2020052688-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-19 | — | — | WO | claimed |
| WO-2019057757-A1 | 1,3-DIHYDROIMIDAZO[4,5-C]CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-03-28 | — | — | WO | claimed |
| US-20060156485-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2006-07-20 | — | — | US | claimed |
| CN-119638634-B | Cinnoline-2-oxide compound, preparation method and application thereof | 上海赛默罗生物科技有限公司 | 2026-01-30 | — | — | CN | disclosed |
| CN-119638634-B | Cinnoline-2-oxide compound, preparation method and application thereof | 上海赛默罗生物科技有限公司 | 2026-01-30 | — | — | CN | disclosed |
| CN-119638634-A | Cinnoline-2-oxide compound, preparation method and application thereof | 上海赛默罗生物科技有限公司 | 2025-03-18 | — | — | CN | disclosed |
| CN-119638634-A | Cinnoline-2-oxide compound, preparation method and application thereof | 上海赛默罗生物科技有限公司 | 2025-03-18 | — | — | CN | disclosed |
| CN-119638634-A | Cinnoline-2-oxide compound, preparation method and application thereof | 上海赛默罗生物科技有限公司 | 2025-03-18 | — | — | CN | disclosed |
| US-20240207263-A1 | SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2024-06-27 | — | — | US | disclosed |
| EP-4308569-A1 | SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | Suzhou Zanrong Pharma Limited (CN) | 2024-01-24 | — | — | EP | disclosed |
| EP-3849984-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-C] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | Suzhou Zanrong Pharma Limited (CN) | 2021-07-21 | — | — | EP | disclosed |
| CN-112752758-A | 1-isopropyl-3-methyl-8- (pyridin-3-yl) -1, 3-dihydro-2H-imidazo [4,5-c ] cinnolin-2-one as selective modulator of ataxia-telangiectasia mutated (ATM) kinase and uses thereof | 苏州赞荣医药科技有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-111344293-A | 1, 3-dihydroimidazo [4, 5-c ] cinnolin-2-one compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-111344293-A | 1, 3-dihydroimidazo [4, 5-c ] cinnolin-2-one compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2020-06-26 | — | — | CN | disclosed |
| WO-2020052688-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020052688-A1 | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-19 | — | — | WO | disclosed |
| WO-2019057757-A1 | 1,3-DIHYDROIMIDAZO[4,5-C]CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-03-28 | — | — | WO | disclosed |
| US-20060156485-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060156485-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | KRT18, TUBB6, DNMT1 | ALDH1A1 385/4885MAPT 1322/4885HPGD 158/4885 |
| US-20240207263-A1 | SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF | ATM, CHEK2, CHEK1 | ALDH1A1 3923/4885MAPT 1185/4885HPGD 3123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.