Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | GLA | P06280 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897222 | 0.87 | ALDH1A1 (0.44) | GLAALDH1A1TSHRMAPTCYP2D6 | |
| SCHEMBL5897067 | 0.85 | ALDH1A1 (0.43) | GLAKMT2AALDH1A1HPGDTSHR | |
| SCHEMBL7683991 | 0.85 | ALDH1A1 (0.43) | GLAALDH1A1TSHRMAPTCYP2D6 | |
| SCHEMBL7683687 | 0.83 | PIK3CB (0.39) | GLAKMT2APOLBALDH1A1TSHR | |
| SCHEMBL5897648 | 0.80 | PIK3CB (0.40) | GLAKMT2ALMNAALDH1A1TSHR | |
| SCHEMBL5897416 | 0.78 | KMT2A (0.39) | KDM4EGLARAB9AKMT2ANPC1 | |
| SCHEMBL5897116 | 0.74 | PIK3CB (0.37) | GAAGLAKMT2ALMNAPOLB | |
| SCHEMBL951715 | 0.70 | KDM4E (0.49) | KDM4EGAAGLARAB9AKMT2A | |
| SCHEMBL3114904 | 0.68 | POLB (0.54) | KDM4EGAAGLARAB9AKMT2A | |
| SCHEMBL949299 | 0.68 | KDM4E (0.48) | KDM4EGAAGLARAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |