Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683991 | 0.97 | ALDH1A1 (0.43) | ALDH1A1SYKKDRGLAPIK3CB | |
| SCHEMBL7683687 | 0.93 | PIK3CB (0.39) | ALDH1A1SYKKDRGLAPIK3CB | |
| SCHEMBL5897076 | 0.87 | KDM4E (0.46) | ALDH1A1GLATSHRHRH3CYP2D6 | |
| SCHEMBL5897067 | 0.87 | ALDH1A1 (0.43) | ALDH1A1SYKGLAPIK3CBPIK3CA | |
| SCHEMBL5897648 | 0.82 | PIK3CB (0.40) | ALDH1A1SYKGLAPIK3CBPIK3CA | |
| SCHEMBL5897416 | 0.80 | KMT2A (0.39) | ALDH1A1GLAPIK3CBPIK3CATSHR | |
| SCHEMBL5897116 | 0.79 | PIK3CB (0.37) | ALDH1A1GLAPIK3CBPIK3CATSHR | |
| SCHEMBL4781313 | 0.68 | KMT2A (0.51) | ALDH1A1PIK3CBTSHRCYP1A2CYP2D6 | |
| SCHEMBL7676555 | 0.68 | CYP1A2 (0.50) | CYP1A2CYP2D6MAPTCRHBPCRHR2 | |
| SCHEMBL23750482 | 0.68 | KDM4E (0.50) | ALDH1A1PIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |
| US-6432949-B1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2002-08-13 | — | — | US | disclosed |