Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 7/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897416 | 0.88 | KMT2A (0.39) | PIK3CBPIK3CAIRAK4PIK3R1KMT2A | |
| SCHEMBL7683687 | 0.83 | PIK3CB (0.39) | PIK3CBPIK3CAPIK3CDKMT2AALDH1A1 | |
| SCHEMBL5897067 | 0.82 | ALDH1A1 (0.43) | PIK3CBPIK3CAPIK3R1KMT2AALDH1A1 | |
| SCHEMBL5897222 | 0.82 | ALDH1A1 (0.44) | PIK3CBPIK3CAALDH1A1GLASYK | |
| SCHEMBL7683991 | 0.80 | ALDH1A1 (0.43) | PIK3CBPIK3CAALDH1A1GLASYK | |
| SCHEMBL5897076 | 0.80 | KDM4E (0.46) | KMT2AALDH1A1GLAHRH3CYP2C19 | |
| SCHEMBL5897116 | 0.77 | PIK3CB (0.37) | PIK3CBPIK3CAPIK3CDPIK3R1KMT2A | |
| SCHEMBL1089064 | 0.72 | ACHE (0.65) | PIK3CBPIK3CAPIK3CDPIK3R1ALDH1A1 | |
| SCHEMBL4781313 | 0.70 | KMT2A (0.51) | PIK3CBKMT2AALDH1A1LMNAPKM | |
| SCHEMBL5897129 | 0.68 | HRH4 (0.55) | PIK3CBKMT2AALDH1A1HRH3CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |