Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897222 | 0.87 | ALDH1A1 (0.44) | ALDH1A1GLATSHRPIK3CBPIK3CA | |
| SCHEMBL7683991 | 0.85 | ALDH1A1 (0.43) | ALDH1A1GLATSHRPIK3CBPIK3CA | |
| SCHEMBL5897076 | 0.85 | KDM4E (0.46) | ALDH1A1GLATSHRHRH3PKM | |
| SCHEMBL7683687 | 0.83 | PIK3CB (0.39) | ALDH1A1GLATSHRPIK3CBPIK3CA | |
| SCHEMBL5897648 | 0.82 | PIK3CB (0.40) | ALDH1A1GLATSHRPIK3CBPIK3CA | |
| SCHEMBL5897416 | 0.80 | KMT2A (0.39) | ALDH1A1GLATSHRPIK3CBPIK3CA | |
| SCHEMBL5897116 | 0.77 | PIK3CB (0.37) | ALDH1A1GLATSHRPIK3CBPIK3CA | |
| SCHEMBL4781313 | 0.70 | KMT2A (0.51) | ALDH1A1TSHRPIK3CBCRHBPCRHR2 | |
| SCHEMBL5897129 | 0.68 | HRH4 (0.55) | ALDH1A1PIK3CBHRH3CRHBPCRHR2 | |
| SCHEMBL5896965 | 0.68 | HRH3 (0.43) | ALDH1A1PIK3CBPIK3CAHRH3CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |