Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 8/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683687 | 0.80 | PIK3CB (0.39) | PIK3CBCRHBPCRHR2PIK3CAPKM | |
| SCHEMBL5897222 | 0.79 | ALDH1A1 (0.44) | PIK3CBCRHBPCRHR2PIK3CATSHR | |
| SCHEMBL7683991 | 0.77 | ALDH1A1 (0.43) | PIK3CBCRHBPCRHR2PIK3CATSHR | |
| SCHEMBL5897067 | 0.77 | ALDH1A1 (0.43) | PIK3CBCRHBPCRHR2PIK3CAPKM | |
| SCHEMBL5897648 | 0.77 | PIK3CB (0.40) | PIK3CBCRHBPCRHR2PIK3CALMNA | |
| SCHEMBL5897416 | 0.75 | KMT2A (0.39) | PIK3CBCRHBPCRHR2PIK3CALMNA | |
| SCHEMBL5897076 | 0.74 | KDM4E (0.46) | LMNAPKMTSHRKMT2AALDH1A1 | |
| SCHEMBL4781313 | 0.70 | KMT2A (0.51) | PIK3CBCRHBPCRHR2LMNAPKM | |
| SCHEMBL5897129 | 0.68 | HRH4 (0.55) | PIK3CBCRHBPCRHR2KMT2AALDH1A1 | |
| SCHEMBL5896965 | 0.68 | HRH3 (0.43) | PIK3CBCRHBPCRHR2PIK3CAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |