Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | PGK1 | P00558 | 3/20 | 0.40 |
| ▸ | PGK2 | P07205 | 3/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | LAP3 | P28838 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897566 | 0.85 | PTPN1 (0.47) | PTPN1PGK1PGK2KCNN4FDPS | |
| SCHEMBL3413596 | 0.82 | PTPN1 (0.60) | PTPN1PGK1PGK2FDPSPTPN5 | |
| Water SCHEMBL5935323 | 0.80 | PTPN1 (0.58) | PTPN1PGK1PGK2FDPSPTPN5 | |
| Water SCHEMBL5162579 | 0.80 | PTPN1 (0.58) | PTPN1PGK1PGK2FDPSPTPN5 | |
| SCHEMBL17169196 | 0.79 | PTPN1 (0.47) | PTPN1PGK1PGK2KCNN4PTPN5 | |
| SCHEMBL2850979 | 0.78 | PTPN1 (0.42) | PTPN1PGK1PGK2KCNN4FDPS | |
| SCHEMBL5897912 | 0.74 | PTPN1 (0.39) | PTPN1PGK1PGK2KCNN4FDPS | |
| SCHEMBL8577397 | 0.73 | LAP3 (0.42) | PTPN1PGK1PGK2KCNN4SMN1; SMN2 | |
| SCHEMBL6813808 | 0.73 | PTPN1 (0.38) | PTPN1PGK1PGK2KCNN4FDPS | |
| SCHEMBL5897909 | 0.70 | FDPS (0.71) | FDPSLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005533-B2 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS 13 (FR) | 2006-02-28 | — | — | US | disclosed |
| US-20040266735-A1 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS 13 | 2004-12-30 | — | — | US | disclosed |
| US-20030036537-A1 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS, 13 (FR) | 2003-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036537-A1 | Bisphosphonate derivatives, their preparations and uses | BPGM, PPIP5K2, PTEN | PTPN1 1016/4885PGK1 86/4885PGK2 108/4885 |
| US-20040266735-A1 | Bisphosphonate derivatives, their preparations and uses | BPGM, PPIP5K2, PTEN | PTPN1 1016/4885PGK1 86/4885PGK2 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.