Sugi Predict

Sugi Predict / Compounds / D-Proline

D-Proline

D-Proline

SCHEMBL5898607

NCCCCCCCCCCCCN.O=C(O)[C@H]1CCCN1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of D-Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRCP P42785 2/20 0.44
▸ NOS2 P35228 2/20 0.42
▸ NOS3 P29474 1/20 0.42
▸ NOS1 P29475 1/20 0.42
▸ MEN1 O00255 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ BLM P54132 1/20 0.40
▸ DPP4 P27487 2/20 0.39
▸ DPP8 Q6V1X1 1/20 0.39
▸ DPP9 Q86TI2 1/20 0.39
▸ ARG1 P05089 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ THRB P10828 2/20 0.38
▸ ALOX15 P16050 2/20 0.38
▸ PLG P00747 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ SLC6A2 P23975 1/20 0.38
▸ RECQL P46063 1/20 0.38
▸ SLC6A3 Q01959 1/20 0.38
▸ CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proline SCHEMBL28323879 0.85 PRCP (0.47) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL419844 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL1125864 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL1429909 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL302680 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
D-Proline SCHEMBL18493080 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL10955251 0.85 PRCP (0.46) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL3097543 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL1675389 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1
Proline SCHEMBL418934 0.85 NOS2 (0.45) PRCPNOS2NOS3NOS1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060165648-A1 Compounds, compositions, and methods for controlling biofilms DEGENHARDT CHARLES R 2006-07-27 — — US disclosed
US-7018642-B2 Compounds, compositions, and methods for controlling biofilms THE PROCTER & GAMBLE COMPANY (US) 2006-03-28 — — US disclosed
US-20030105072-A1 Compounds, compositions, and methods for controlling biofilms THE PROCTER & GAMBLE COMPANY 2003-06-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060165648-A1 Compounds, compositions, and methods for controlling biofilms BMP2, BMP1, BMP4 PRCP 3054/4885NOS2 190/4885NOS3 153/4885
US-20030105072-A1 Compounds, compositions, and methods for controlling biofilms BMP2, BMP1, BMP4 PRCP 3054/4885NOS2 190/4885NOS3 153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.