Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ABL1 | P00519 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | IDE | P14735 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | HLCS | P50747 | 6/20 | 0.64 |
| ▸ | CA12 | O43570 | 6/20 | 0.60 |
| ▸ | CA1 | P00915 | 6/20 | 0.60 |
| ▸ | CA2 | P00918 | 6/20 | 0.60 |
| ▸ | CA9 | Q16790 | 6/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899174 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL4757050 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL13274150 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL8165184 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL13524253 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL10171679 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL12238074 | 1.00 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL24653263 | 0.99 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL15130533 | 0.96 | TDP1 (0.67) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL26902859 | 0.93 | TDP1 (0.69) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236082-B2 | EZH2 inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| EP-3885343-A1 | INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| WO-2020185610-A1 | NEW TECHNOLOGY TO CONJUGATE THE TACCALONOLIDE MICROTUBULE STABILIZERS WITH LINKERS/PAYLOADS | DU LIN (US) | 2020-09-17 | — | — | WO | disclosed |
| US-10765681-B2 | Purine compounds possessing anticancer activity | ACADEMIA SINICA (TW) | 2020-09-08 | — | — | US | disclosed |
| US-10633371-B2 | EZH2 inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20200039968-A9 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-06 | — | — | US | disclosed |
| WO-2019154306-A1 | SACCHARIDE DERIVATIVES FOR IMMUNE CELL SURFACE MODIFICATION AND USE THEREOF | 厦门诺康得生物科技有限公司 | 2019-08-15 | — | — | WO | disclosed |
| WO-2019136442-A1 | CD16A BINDING AGENTS AND USES THEREOF | KLEO PHARMACEUTICALS, INC. (US) | 2019-07-11 | — | — | WO | disclosed |
| US-20190135796-A1 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-05-09 | — | — | US | disclosed |
| US-10202400-B2 | Cortistatin analogues and syntheses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-02-12 | — | — | US | disclosed |
| US-8389223-B2 | Probes for anionic cell surface detection | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2013-03-05 | — | — | US | disclosed |
| US-20110262991-A1 | Living Copolymer-Protein/Peptide Hybrids for Biomedical Applications | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2011-10-27 | — | — | US | disclosed |
| US-20100331542-A1 | PROBES FOR ANIONIC CELL SURFACE DETECTION | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331542-A1 | PROBES FOR ANIONIC CELL SURFACE DETECTION | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010108058-A2 | SMALL MOLECULE INHIBITORS OF DUSP6 AND USES THEREFOR | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-09-23 | — | — | WO | disclosed |
| US-20080171351-A1 | PROBES FOR ANIONIC CELL SURFACE DETECTION | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2008-07-17 | — | — | US | disclosed |
| US-20080171351-A1 | PROBES FOR ANIONIC CELL SURFACE DETECTION | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2008-07-17 | — | — | US | disclosed |
| US-7141676-B1 | Water soluble multi-biotin-containing compounds | UNIVERSITY OF WASHINGTON (US) | 2006-11-28 | — | — | US | disclosed |
| US-20060228325-A1 | Water soluble multi-biotin-containing compounds | WILBUR D S | 2006-10-12 | — | — | US | disclosed |
| WO-2006044063-A2 | TRANSEPITHELIAL DELIVERY OF PEPTIDES WITH INCRETIN HORMONE ACTIVITIES | NITTO DENKO CORPORATION (JP) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135796-A1 | EZH2 INHIBITORS AND USES THEREOF | EZH2, EZH1, BMI1 | TDP1 2354/4885MEN1 1551/4885ABL1 375/4885 |
| US-20200039968-A9 | EZH2 INHIBITORS AND USES THEREOF | EZH2, EZH1, BMI1 | TDP1 2354/4885MEN1 1551/4885ABL1 375/4885 |
| US-10202400-B2 | Cortistatin analogues and syntheses thereof | CTTN, TEK, FLT1 | TDP1 4363/4885MEN1 110/4885ABL1 1123/4885 |
| US-20060228325-A1 | Water soluble multi-biotin-containing compounds | BTD, HLCS, VNN1 | TDP1 2706/4885MEN1 3462/4885ABL1 4752/4885 |
| US-20100331542-A1 | PROBES FOR ANIONIC CELL SURFACE DETECTION | ANXA5, ANXA6, ANXA3 | TDP1 2117/4885MEN1 2512/4885ABL1 992/4885 |
| US-10765681-B2 | Purine compounds possessing anticancer activity | NTPCR, PNP, NUDT1 | TDP1 141/4885MEN1 1587/4885ABL1 1367/4885 |
| US-10633371-B2 | EZH2 inhibitors and uses thereof | EZH2, EZH1, BMI1 | TDP1 2354/4885MEN1 1551/4885ABL1 375/4885 |
| US-11236082-B2 | EZH2 inhibitors and uses thereof | EZH2, EZH1, BMI1 | TDP1 2226/4885MEN1 1860/4885ABL1 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.