SCHEMBL8165184

SCHEMBL8165184

CNC(=O)CCCCC1SCC2NC(=O)NC21

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 5/20 0.73
▸ MEN1 O00255 1/20 0.71
▸ ABL1 P00519 1/20 0.71
▸ LMNA P02545 1/20 0.71
▸ PKM P14618 1/20 0.71
▸ IDE P14735 1/20 0.71
▸ MAPK1 P28482 1/20 0.71
▸ KMT2A Q03164 1/20 0.71
▸ RIN1 Q13671 1/20 0.71
▸ L3MBTL1 Q9Y468 1/20 0.71
▸ HLCS P50747 6/20 0.64
▸ CA12 O43570 6/20 0.60
▸ CA1 P00915 6/20 0.60
▸ CA2 P00918 6/20 0.60
▸ CA9 Q16790 6/20 0.60
▸ F2 P00734 1/20 0.53
▸ PRSS1 P07477 1/20 0.53
▸ PRSS2 P07478 1/20 0.53
▸ PRSS3 P35030 1/20 0.53
▸ TPSAB1 Q15661 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13899174 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL4757050 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL13274150 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL5903676 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL13524253 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL10171679 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL12238074 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL24653263 0.99 TDP1 (0.71) TDP1MEN1ABL1LMNAPKM
SCHEMBL15130533 0.96 TDP1 (0.67) TDP1MEN1ABL1LMNAPKM
SCHEMBL26902859 0.93 TDP1 (0.69) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023173079-A2 NONCOVALENTLY BRANCHED OLIGONUCLEOTIDE COMPOSITIONS ATALANTA THERAPEUTICS, INC. (US) 2023-09-14 — — WO disclosed
US-20230159762-A1 NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION REVVITY HEALTH SCIENCES, INC. 2023-05-25 — — US disclosed
US-11549017-B2 NIR to SWIR fluorescent compounds for imaging and detection PERKINELMER HEALTH SCIENCES, INC. (US) 2023-01-10 — — US disclosed
US-10995004-B2 Method for functionalizing carbon nanoparticles and compositions THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-05-04 — — US disclosed
US-20200207627-A1 METHOD FOR FUNCTIONALIZING CARBON NANOPARTICLES AND COMPOSITIONS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2020-07-02 — — US disclosed
WO-2020132588-A1 COMBINATION THERAPY OF ARMS AND NATURAL KILLER CELLS KLEO PHARMACEUTICALS, INC. (US) 2020-06-25 — — WO disclosed
EP-3228631-B1 TREATING RESPIRATORY CONDITIONS TLA TARGETED IMMUNOTHERAPIES AB (SE) 2020-06-24 — — EP disclosed
EP-2717940-B1 TREATING CONDITIONS ASSOCIATED WITH METABOLIC SYNDROME TLA TARGETED IMMUNOTHERAPIES AB (SE) 2020-04-22 — — EP disclosed
US-10451620-B2 Treating conditions associated with metabolic syndrome TLA TARGETED IMMUNOTHERAPIES AB (SE) 2019-10-22 — — US disclosed
US-10429385-B2 Treating conditions associated with sepsis TLA TARGETED IMMUNOTHERAPIES AB (SE) 2019-10-01 — — US disclosed
US-7618944-B2 Encapsulating in micelle which is a block copolymer containing hydrophilic and hydrophobic blocks INTEZYNE TECHNOLOGIES, INC. (US) 2009-11-17 — — US disclosed
US-20090048123-A1 Reagentless and Reusable Biosensors with Tunable Differential Binding Affinities and Methods of Making THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2009-02-19 — — US disclosed
US-7468243-B2 Nucleotide sequence labelling compoumd four use as tool in genetic engineering AFFYMETRIX, INC. (US) 2008-12-23 — — US disclosed
WO-2008134734-A2 ENCAPSULATED CONTRAST AGENTS INTEZYNE TECHNOLOGIES, INC. (US) 2008-11-06 — — WO disclosed
US-20080274965-A1 ENCAPSULATED AMYLOID-BETA PEPTIDES INTEZYNE TECHNOLOGIES, INC. (US) 2008-11-06 — — US disclosed
WO-2008134731-A1 HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS INTEZYNE TECHNOLOGIES, INC. (US) 2008-11-06 — — WO disclosed
US-20080262254-A1 Sphingolipids ETTMAYER PETER 2008-10-23 — — US disclosed
US-20080262254-A1 Sphingolipids ETTMAYER PETER 2008-10-23 — — US disclosed
US-7435386-B2 Biorecognition element, a modular arm element labeled with a second signaling module, a detector for detecting a change in fluorescence resonance energy transfer (FRET) THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2008-10-14 — — US disclosed
WO-2008106657-A2 ENCAPSULATED AMYLOID-BETA PEPTIDES INTEZYNE TECHNOLOGIES, INC. (US) 2008-09-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080274965-A1 ENCAPSULATED AMYLOID-BETA PEPTIDES IAPP, APP, TTR TDP1 2067/4885MEN1 227/4885ABL1 4641/4885
US-20200207627-A1 METHOD FOR FUNCTIONALIZING CARBON NANOPARTICLES AND COMPOSITIONS TERT, CA13, PCCA TDP1 3965/4885MEN1 1660/4885ABL1 1064/4885
US-10995004-B2 Method for functionalizing carbon nanoparticles and compositions TERT, CA13, PCCA TDP1 3965/4885MEN1 1660/4885ABL1 1064/4885
US-20080262254-A1 Sphingolipids SGMS2, SGMS1, SGPL1 TDP1 1903/4885MEN1 376/4885ABL1 2776/4885
US-11549017-B2 NIR to SWIR fluorescent compounds for imaging and detection SMARCD1, SMARCE1, SMARCB1 TDP1 1295/4885MEN1 1886/4885ABL1 4400/4885
US-20230159762-A1 NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION SMARCD1, SMARCE1, SMARCB1 TDP1 1295/4885MEN1 1886/4885ABL1 4400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback