SCHEMBL4757050

SCHEMBL4757050

CNC(=O)CCCCC1SC[C@H]2NC(=O)N[C@@H]12

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 5/20 0.73
▸ MEN1 O00255 1/20 0.71
▸ ABL1 P00519 1/20 0.71
▸ LMNA P02545 1/20 0.71
▸ PKM P14618 1/20 0.71
▸ IDE P14735 1/20 0.71
▸ MAPK1 P28482 1/20 0.71
▸ KMT2A Q03164 1/20 0.71
▸ RIN1 Q13671 1/20 0.71
▸ L3MBTL1 Q9Y468 1/20 0.71
▸ HLCS P50747 6/20 0.64
▸ CA12 O43570 6/20 0.60
▸ CA1 P00915 6/20 0.60
▸ CA2 P00918 6/20 0.60
▸ CA9 Q16790 6/20 0.60
▸ F2 P00734 1/20 0.53
▸ PRSS1 P07477 1/20 0.53
▸ PRSS2 P07478 1/20 0.53
▸ PRSS3 P35030 1/20 0.53
▸ TPSAB1 Q15661 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13899174 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL13274150 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL5903676 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL8165184 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL13524253 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL10171679 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL12238074 1.00 TDP1 (0.73) TDP1MEN1ABL1LMNAPKM
SCHEMBL24653263 0.99 TDP1 (0.71) TDP1MEN1ABL1LMNAPKM
SCHEMBL15130533 0.96 TDP1 (0.67) TDP1MEN1ABL1LMNAPKM
SCHEMBL26902859 0.93 TDP1 (0.69) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722028-B2 Ethylenic copolymers, compositions and methods of the same L'OREAL (FR) 2014-05-13 — — US disclosed
US-8722028-B2 Ethylenic copolymers, compositions and methods of the same L'OREAL (FR) 2014-05-13 — — US disclosed
US-20140023607-A1 NOVEL ETHYLENIC COPOLYMERS, COMPOSITIONS AND METHODS OF THE SAME L'OREAL (FR) 2014-01-23 — — US disclosed
US-20140023607-A1 NOVEL ETHYLENIC COPOLYMERS, COMPOSITIONS AND METHODS OF THE SAME L'OREAL (FR) 2014-01-23 — — US disclosed
US-20140023608-A1 NOVEL ETHYLENIC COPOLYMERS, COMPOSITIONS AND METHODS OF THE SAME L'OREAL (FR) 2014-01-23 — — US disclosed
US-20140023608-A1 NOVEL ETHYLENIC COPOLYMERS, COMPOSITIONS AND METHODS OF THE SAME L'OREAL (FR) 2014-01-23 — — US disclosed
EP-2168991-B1 New ethylene copolymeres, compositions comprising the same and treatment method OREAL (FR) 2013-10-09 — — EP disclosed
US-8298513-B2 Hexatriene-β-carbonyl compound OSAKA UNIVERSITY (JP) 2012-10-30 — — US disclosed
EP-1765893-B1 NOVEL ETHYLENE COPOLYMERS, COMPOSITIONS COMPRISING SAME AND PREPARATION AND TREATMENT METHODS OREAL (FR) 2012-08-22 — — EP disclosed
US-8178079-B2 Ethylene copolymers, compositions containing said copolymers and treatment method L'OREAL S.A. (FR) 2012-05-15 — — US disclosed
EP-2087881-A1 Dispersion of polymer particles, composition comprising same and cosmetic treatment method L'Oréal (FR) 2009-08-12 — — EP disclosed
US-20090196839-A1 DISPERSION OF POLYMER PARTICLES, COMPOSITION COMPRISING SAME AND COSMETIC TREATMENT METHOD L'OREAL S.A. (FR) 2009-08-06 — — US disclosed
US-20090196839-A1 DISPERSION OF POLYMER PARTICLES, COMPOSITION COMPRISING SAME AND COSMETIC TREATMENT METHOD L'OREAL S.A. (FR) 2009-08-06 — — US disclosed
US-20080311066-A1 Cosmetics Compositions Comprising at Least One Surfactant and at Least One Novel Ethylene Copolymer with Polyethylene Glycol Grafts L'ORÉAL (FR) 2008-12-18 — — US disclosed
US-20080311066-A1 Cosmetics Compositions Comprising at Least One Surfactant and at Least One Novel Ethylene Copolymer with Polyethylene Glycol Grafts L'ORÉAL (FR) 2008-12-18 — — US disclosed
US-20080286218-A1 Cosmetic Compositions Containing at Least One Conditioning Agent and at Least One Ethylene Polymer with Polyethylene Glycol Grafts L'OREAL S.A. (FR) 2008-11-20 — — US disclosed
US-20080286218-A1 Cosmetic Compositions Containing at Least One Conditioning Agent and at Least One Ethylene Polymer with Polyethylene Glycol Grafts L'OREAL S.A. (FR) 2008-11-20 — — US disclosed
WO-2008104696-A2 POLYMER PARTICLE DISPERSION, COMPOSITION CONTAINING THE SAME AND COSMETIC TREATMENT METHOD L'OREAL (FR) 2008-09-04 — — WO disclosed
US-20080014154-A1 Novel Ethylene Copolymers, Compositions Containing Said Copolymers and Treatment Method L'OREAL S.A. (FR) 2008-01-17 — — US disclosed
US-20080014154-A1 Novel Ethylene Copolymers, Compositions Containing Said Copolymers and Treatment Method L'OREAL S.A. (FR) 2008-01-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140023608-A1 NOVEL ETHYLENIC COPOLYMERS, COMPOSITIONS AND METHODS OF THE SAME ERCC1, ERCC5, ACP1 TDP1 64/4885MEN1 1500/4885ABL1 3383/4885
US-20080311066-A1 Cosmetics Compositions Comprising at Least One Surfactant and at Least One Novel Ethylene Copolymer with Polyethylene Glycol Grafts ACMSD, ERCC1, ASS1 TDP1 1396/4885MEN1 96/4885ABL1 4760/4885
US-20140023607-A1 NOVEL ETHYLENIC COPOLYMERS, COMPOSITIONS AND METHODS OF THE SAME ERCC1, ERCC5, ACP1 TDP1 64/4885MEN1 1500/4885ABL1 3383/4885
US-20080286218-A1 Cosmetic Compositions Containing at Least One Conditioning Agent and at Least One Ethylene Polymer with Polyethylene Glycol Grafts SGMS2, SGMS1, SMS TDP1 3609/4885MEN1 712/4885ABL1 3821/4885
US-20080014154-A1 Novel Ethylene Copolymers, Compositions Containing Said Copolymers and Treatment Method MMAB, SGMS2, SGMS1 TDP1 1206/4885MEN1 764/4885ABL1 1886/4885
US-20090196839-A1 DISPERSION OF POLYMER PARTICLES, COMPOSITION COMPRISING SAME AND COSMETIC TREATMENT METHOD KRT18, CUTA, DEK TDP1 2367/4885MEN1 1851/4885ABL1 3547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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