Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103942 | 0.73 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL5983948 | 0.66 | SLC6A3 (0.37) | LMNADRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5981666 | 0.65 | ALDH1A1 (0.35) | KMT2ALMNA | |
| SCHEMBL2203029 | 0.64 | SLC6A2 (0.41) | LMNADRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4112531 | 0.63 | — | — | |
| SCHEMBL4353639 | 0.63 | KDM4E (0.40) | MEN1KMT2ALMNASLC6A2SLC6A3 | |
| SCHEMBL3870566 | 0.63 | ADRA1A (0.40) | — | |
| SCHEMBL4104379 | 0.62 | HRH4 (0.31) | — | |
| SCHEMBL6648965 | 0.62 | CYP1A2 (0.38) | LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4344619 | 0.61 | PARP1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | disclosed |