Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5986679 | 0.98 | LMNA (0.49) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10257278 | 0.91 | LMNA (0.57) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL5987270 | 0.88 | LMNA (0.41) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10256807 | 0.86 | L3MBTL1 (0.55) | LMNATSHRL3MBTL1CYP3A4MAPK1 | |
| Iodide SCHEMBL2761176 | 0.85 | L3MBTL1 (0.54) | LMNATSHRL3MBTL1CYP3A4MAPK1 | |
| SCHEMBL28686609 | 0.82 | TDP1 (0.65) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL3200587 | 0.82 | TDP1 (0.65) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL3200610 | 0.82 | TDP1 (0.65) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL15080523 | 0.82 | TDP1 (0.65) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL2761345 | 0.81 | STS (0.48) | LMNAALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060173053-A1 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-08-03 | — | — | US | claimed |
| EP-1551495-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-07-13 | — | — | EP | claimed |
| WO-2004032824-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-04-22 | — | — | WO | claimed |
| US-8987263-B2 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-03-24 | — | — | US | disclosed |
| US-20060173053-A1 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-08-03 | — | — | US | disclosed |
| EP-1551495-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004032824-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173053-A1 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | ALOX12, ALOX15, ALOX15B | LMNA 3706/4885ALDH1A1 447/4885MAPT 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.