Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Scyllitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITPR3 | Q14573 | 8/20 | 0.64 |
| ▸ | ITPR2 | Q14571 | 4/20 | 0.60 |
| ▸ | ITPR1 | Q14643 | 4/20 | 0.60 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.56 |
| ▸ | INPP5A | Q14642 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930713 | 0.91 | ITPR3 (0.71) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL4343591 | 0.91 | ITPR3 (0.74) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL6664274 | 0.91 | ITPR3 (0.74) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL7035469 | 0.91 | ITPR3 (0.71) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL4343592 | 0.91 | ITPR3 (0.74) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL3500008 | 0.91 | ITPR3 (0.56) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL6708568 | 0.91 | ITPR3 (0.56) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL3498450 | 0.91 | ITPR3 (0.56) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL613185 | 0.91 | ITPR3 (0.56) | ITPR3ITPR2ITPR1INPPL1AKT1 | |
| SCHEMBL29869445 | 0.91 | ITPR3 (0.56) | ITPR3ITPR2ITPR1INPPL1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060286639-A1 | Complementary DNAs encoding proteins with signal peptides | SERONO GENETICS INSTITUTE S.A. (FR) | 2006-12-21 | — | — | US | disclosed |
| US-20060223142-A1 | Extended cDNAs for secreted proteins | SERONO GENETICS INSTITUTE S.A. (FR) | 2006-10-05 | — | — | US | disclosed |
| US-7056680-B2 | Antibodies to claudin-50 polypeptide | SERONO GENETICS INSTITUTE S.A. (FR) | 2006-06-06 | — | — | US | disclosed |
| US-20060009633-A9 | Complementary DNAs encoding proteins with signal peptides | GENSET, S.A. (FR) | 2006-01-12 | — | — | US | disclosed |
| US-20040110939-A1 | Complementary DNAs encoding proteins with signal peptides | GENSET, S.A. (FR) | 2004-06-10 | — | — | US | disclosed |
| US-20030144490-A1 | Extended cDNAs for secreted proteins | SERONO GENETICS INSTITUTE S.A. (FR) | 2003-07-31 | — | — | US | disclosed |
| US-6573068-B1 | Purified and isolated polypeptide of given amino acid sequence; cDNA can be used to express it or to obtain antibodies that specifically bind to it | GENSET, S. A. (FR) | 2003-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144490-A1 | Extended cDNAs for secreted proteins | DNASE1L3, DNAJC10, PRSS12 | ITPR3 4294/4885ITPR2 4489/4885ITPR1 4573/4885 |
| US-20060223142-A1 | Extended cDNAs for secreted proteins | DNASE1L3, DNAJC10, PRSS12 | ITPR3 4294/4885ITPR2 4489/4885ITPR1 4573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.