Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.64 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.62 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 11/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.62 |
| ▸ | LMNA | P02545 | 7/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.62 |
| ▸ | USP2 | O75604 | 3/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201446 | 0.82 | ALDH1A1 (0.80) | PDE5AABCG2TGFBR1ABCB1ABCC1 | |
| SCHEMBL6001182 | 0.81 | HSD17B10 (0.49) | TGFBR1MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL6001170 | 0.81 | LMNA (0.77) | ABCG2TGFBR1MEN1KMT2ALMNA | |
| SCHEMBL7440311 | 0.81 | PDE5A (1.00) | PDE5AABCG2ABCB1ABCC1MEN1 | |
| SCHEMBL6001908 | 0.80 | PTGS2 (0.49) | TGFBR1MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL12316850 | 0.79 | MEN1 (0.73) | ABCG2TGFBR1ABCB1MEN1KMT2A | |
| SCHEMBL2293460 | 0.78 | MEN1 (0.69) | ABCG2TGFBR1ABCB1MEN1KMT2A | |
| SCHEMBL3114780 | 0.78 | TGFBR1 (0.62) | ABCG2TGFBR1MEN1KMT2ALMNA | |
| SCHEMBL9937633 | 0.77 | ABCG2 (0.74) | PDE5AABCG2TGFBR1ABCB1ABCC1 | |
| SCHEMBL6001863 | 0.76 | GBA1 (0.52) | PDE5AABCG2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | REDDY US THERAPEUTICS, INC. | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | HPSE, ENGASE, UGCG | PDE5A 3180/4885ABCG2 2694/4885TGFBR1 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.