Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945830 | 0.71 | ALDH1A1 (0.56) | LMNASMN1; SMN2CTSDNPSR1TDP1 | |
| SCHEMBL5320162 | 0.70 | HPGD (0.41) | SMN1; SMN2POLBPAX8TLR9TDP1 | |
| SCHEMBL27656415 | 0.69 | PAX8 (0.43) | ESR1SMN1; SMN2POLBPAX8TLR9 | |
| SCHEMBL2095223 | 0.69 | CHRNB2 (0.41) | LMNASMN1; SMN2 | |
| SCHEMBL7824932 | 0.68 | TSPO (0.44) | LMNAESR1SMN1; SMN2POLBCTSD | |
| SCHEMBL9625766 | 0.68 | ALDH1A1 (0.41) | LMNAPTGIRESR1SMN1; SMN2POLB | |
| SCHEMBL10424602 | 0.66 | CA1 (0.50) | LMNAPTGIRSMN1; SMN2POLBCTSD | |
| SCHEMBL514005 | 0.66 | TSPO (0.45) | ESR1SMN1; SMN2POLBNPSR1PAX8 | |
| SCHEMBL5012682 | 0.66 | NPSR1 (0.50) | LMNASMN1; SMN2NPSR1 | |
| SCHEMBL2214193 | 0.66 | CA1 (0.48) | LMNAESR1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |