Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743274 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7290719 | 0.80 | HTR1D (0.52) | ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL7283686 | 0.79 | CYP1A1 (0.58) | ALDH1A1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7283674 | 0.79 | CYP1A1 (0.58) | ALDH1A1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL28959155 | 0.79 | MEN1 (0.62) | ALDH1A1HPGDKDM4ERAB9AMEN1 | |
| SCHEMBL2208967 | 0.78 | KDM4E (0.64) | ALDH1A1KDM4ESMN1; SMN2KMT2AHSD17B10 | |
| SCHEMBL19211173 | 0.78 | RHEB (0.53) | RAB9ANPC1KMT2APOLB | |
| SCHEMBL7283679 | 0.78 | MAPT (0.46) | ALDH1A1HPGDKDM4ERAB9ANPC1 | |
| SCHEMBL372048 | 0.76 | IMPDH2 (0.58) | ALDH1A1HPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6935037 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503439-B2 | Heteroaryl compounds for the treatment of pain | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-12-23 | — | — | US | disclosed |
| EP-4416146-A1 | SUBSTITUTED 1H-PYRAZOLO [4,3-C] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF | Lomond Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| CN-118076605-A | Substituted 1H-pyrazolo [4,3-c ] quinolines, methods of preparation and uses thereof | 洛蒙治疗公司 | 2024-05-24 | — | — | CN | disclosed |
| US-20230373925-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED | 2023-11-23 | — | — | US | disclosed |
| WO-2023064133-A1 | SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF | LOMOND THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| EP-3414229-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | Pharmakea, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139274-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-08-17 | — | — | WO | disclosed |
| US-9656948-B2 | Compound, optical resolution method, and derivative of an optical isomer of an amino acid | SHISEIDO COMPANY, LTD. (JP) | 2017-05-23 | — | — | US | disclosed |
| US-20160039743-A1 | COMPOUND, OPTICAL RESOLUTION METHOD, AND DERIVATIVE OF AN OPTICAL ISOMER OF AN AMINO ACID | SHISEIDO COMPANY, LTD. (JP) | 2016-02-11 | — | — | US | disclosed |
| US-9193684-B2 | Compound, optical resolution method, and derivative of an optical isomer of an amino acid | SHISEIDO COMPANY, LTD. (JP) | 2015-11-24 | — | — | US | disclosed |
| US-20150065716-A1 | COMPOUND, OPTICAL RESOLUTION METHOD, AND DERIVATIVE OF AN OPTICAL ISOMER OF AN AMINO ACID | SHISEIDO COMPANY, LTD. (JP) | 2015-03-05 | — | — | US | disclosed |
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065716-A1 | COMPOUND, OPTICAL RESOLUTION METHOD, AND DERIVATIVE OF AN OPTICAL ISOMER OF AN AMINO ACID | BCAT2, BCAT1, AADAT | ALDH1A1 2978/4885HPGD 3011/4885KDM4E 4421/4885 |
| US-20160039743-A1 | COMPOUND, OPTICAL RESOLUTION METHOD, AND DERIVATIVE OF AN OPTICAL ISOMER OF AN AMINO ACID | BCAT2, BCAT1, AADAT | ALDH1A1 2978/4885HPGD 3011/4885KDM4E 4421/4885 |
| US-20230373925-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | TRPV1, SCN3A, KCNN3 | ALDH1A1 1762/4885HPGD 546/4885KDM4E 4346/4885 |
| US-12503439-B2 | Heteroaryl compounds for the treatment of pain | TRPV1, SCN3A, KCNN3 | ALDH1A1 1762/4885HPGD 546/4885KDM4E 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.