Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004233 | 0.85 | SRC (0.34) | TGFBR1 | |
| SCHEMBL6005275 | 0.83 | PDGFRB (0.52) | TGFBR1 | |
| SCHEMBL6005256 | 0.82 | PDGFRB (0.36) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6004179 | 0.82 | CYP3A4 (0.44) | — | |
| SCHEMBL6004228 | 0.81 | AXL (0.34) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6004067 | 0.81 | SLC22A12 (0.38) | — | |
| SCHEMBL6004897 | 0.80 | MET (0.48) | — | |
| SCHEMBL6003010 | 0.77 | PDE3B (0.41) | TGFBR1APP | |
| SCHEMBL6005209 | 0.77 | MET (0.41) | — | |
| SCHEMBL6004288 | 0.77 | KDR (0.41) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |