Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | TEK | Q02763 | 4/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004758 | 0.86 | MET (0.42) | KDRAURKAMETTEKAURKB | |
| SCHEMBL6004233 | 0.81 | SRC (0.34) | SRCTGFBR1 | |
| SCHEMBL6004277 | 0.80 | NPSR1 (0.43) | KDRAURKAMETTEKAURKB | |
| SCHEMBL6004278 | 0.80 | KDR (0.49) | KDRAURKAMETTEKAURKB | |
| SCHEMBL6005275 | 0.79 | PDGFRB (0.52) | KDRMETSRCTGFBR1 | |
| SCHEMBL6005293 | 0.77 | THRB (0.36) | TGFBR1 | |
| SCHEMBL6004897 | 0.76 | MET (0.48) | KDRMET | |
| SCHEMBL6005209 | 0.75 | MET (0.41) | KDRMET | |
| SCHEMBL6003010 | 0.75 | PDE3B (0.41) | KDRAURKAMETTEKAURKB | |
| SCHEMBL6004067 | 0.74 | SLC22A12 (0.38) | KDRAURKAMETTEKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |