Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.35 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004233 | 0.88 | SRC (0.34) | KDM4ETGFBR1SRCHPGDALDH1A1 | |
| SCHEMBL6005330 | 0.86 | TGFBR1 (0.46) | CBFBRETRIPK1RIPK3KDM4E | |
| SCHEMBL6004710 | 0.85 | CYP3A4 (0.42) | CBFBKDM4ENPC1HPGDRAB9A | |
| SCHEMBL6004207 | 0.85 | CYP1A2 (0.37) | CBFBKDM4ENPC1TGFBR1MAPT | |
| SCHEMBL6004857 | 0.84 | SRC (0.37) | KDM4ETGFBR1SRCMAPTHPGD | |
| SCHEMBL6002914 | 0.84 | PDGFRB (0.49) | TGFBR1SRCMETKDRMST1R | |
| SCHEMBL6005438 | 0.82 | MET (0.35) | CBFBKDM4ENPC1TGFBR1MAPT | |
| SCHEMBL6004984 | 0.81 | PDE3B (0.39) | CBFBKDM4ENPC1TGFBR1SRC | |
| SCHEMBL6004725 | 0.81 | TGFBR1 (0.48) | CBFBRETRIPK1RIPK3KDM4E | |
| SCHEMBL6005260 | 0.81 | MET (0.50) | TGFBR1SRCMETKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |