Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004276 | 0.91 | LMNA (0.39) | KDRBRAFCYP3A4SYKLMNA | |
| SCHEMBL6002787 | 0.80 | CCNC (0.39) | BRAFMAPK14DHODH | |
| SCHEMBL6004327 | 0.79 | TOP1 (0.42) | KDM4ELMNAMAPK14DHODHMAPT | |
| SCHEMBL6005302 | 0.79 | DHODH (0.39) | HTTKDM4EMAPK14DHODH | |
| SCHEMBL6004812 | 0.78 | FGFR2 (0.44) | KDR | |
| SCHEMBL6004803 | 0.77 | FGFR2 (0.36) | KDRDHODH | |
| SCHEMBL6004795 | 0.77 | FGFR2 (0.36) | KDRMAPK14DHODH | |
| SCHEMBL6004736 | 0.77 | KDM4E (0.48) | KDRCYP3A4KDM4E | |
| SCHEMBL6005261 | 0.77 | KDM4E (0.49) | CYP1A2CYP2C19KDRCYP3A4KDM4E | |
| SCHEMBL6004130 | 0.77 | PGK1 (0.35) | KDRBRAFCYP3A4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |