Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 5/20 | 0.39 |
| ▸ | CDK8 | P49336 | 5/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004276 | 0.88 | LMNA (0.39) | NPC1DHODHBRAF | |
| SCHEMBL6005302 | 0.83 | DHODH (0.39) | CCNCCDK8DHODHMAPK14 | |
| SCHEMBL6004795 | 0.82 | FGFR2 (0.36) | NPC1DHODHMAPK14 | |
| SCHEMBL6004803 | 0.82 | FGFR2 (0.36) | NPC1DHODH | |
| SCHEMBL6005261 | 0.81 | KDM4E (0.49) | — | |
| SCHEMBL6004327 | 0.81 | TOP1 (0.42) | NPC1DHODHMAPK14 | |
| SCHEMBL3895779 | 0.81 | FGFR2 (0.53) | — | |
| SCHEMBL6005353 | 0.81 | CCNC (0.40) | CCNCCDK8DHODHMAPK14BRAF | |
| SCHEMBL6004728 | 0.80 | CYP1A2 (0.37) | DHODHMAPK14BRAF | |
| SCHEMBL6004736 | 0.79 | KDM4E (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |