Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 3/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.39 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.39 |
| ▸ | STK16 | O75716 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005302 | 0.86 | DHODH (0.39) | CCNCCDK8TOP1DHODHMAPK14 | |
| SCHEMBL6004276 | 0.84 | LMNA (0.39) | TOP1DHODHBRAFKDR | |
| SCHEMBL6004795 | 0.83 | FGFR2 (0.36) | TOP1DHODHKDRMAPK14MET | |
| SCHEMBL6005261 | 0.82 | KDM4E (0.49) | TOP1KDRGAKRIPK2NLK | |
| SCHEMBL6002787 | 0.81 | CCNC (0.39) | CCNCCDK8DHODHBRAFMAPK14 | |
| SCHEMBL6004803 | 0.81 | FGFR2 (0.36) | DHODHKDR | |
| SCHEMBL3895779 | 0.80 | FGFR2 (0.53) | KDREGFR | |
| SCHEMBL6004093 | 0.78 | MET (0.45) | KDRMET | |
| SCHEMBL6004849 | 0.78 | MET (0.45) | KDRMET | |
| SCHEMBL6004327 | 0.78 | TOP1 (0.42) | TOP1DHODHMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |