Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004795 | 0.88 | FGFR2 (0.36) | DHODHMAPK14TOP1FGFR2 | |
| SCHEMBL6004276 | 0.87 | LMNA (0.39) | DHODHALDH1A1TOP1 | |
| SCHEMBL6005353 | 0.86 | CCNC (0.40) | DHODHMAPK14CCNCCDK8TOP1 | |
| SCHEMBL6005261 | 0.85 | KDM4E (0.49) | KDM4EMEN1ALDH1A1KMT2ATOP1 | |
| SCHEMBL6002787 | 0.83 | CCNC (0.39) | DHODHMAPK14CCNCCDK8 | |
| SCHEMBL6004803 | 0.83 | FGFR2 (0.36) | DHODHFGFR2 | |
| SCHEMBL6004849 | 0.83 | MET (0.45) | FGFR2 | |
| SCHEMBL6004093 | 0.83 | MET (0.45) | FGFR2 | |
| SCHEMBL3895779 | 0.82 | FGFR2 (0.53) | FGFR2 | |
| SCHEMBL6004223 | 0.82 | PDGFRA (0.48) | FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |