Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004093 | 0.91 | MET (0.45) | FGFR2METKDRMST1RAXL | |
| SCHEMBL6004849 | 0.91 | MET (0.45) | FGFR2METKDRMST1RAXL | |
| SCHEMBL6005302 | 0.88 | DHODH (0.39) | FGFR2MAPK14TOP1DHODH | |
| SCHEMBL6004803 | 0.86 | FGFR2 (0.36) | FGFR2KDRAXLSRCTGFBR1 | |
| SCHEMBL6004276 | 0.86 | LMNA (0.39) | KDRTOP1NPC1DHODH | |
| SCHEMBL3895779 | 0.85 | FGFR2 (0.53) | FGFR2KDRAXLSRCTGFBR1 | |
| SCHEMBL6005306 | 0.84 | MAPK14 (0.34) | METMST1RMAPK14TOP1NPC1 | |
| SCHEMBL6005353 | 0.83 | CCNC (0.40) | METKDRMAPK14TOP1DHODH | |
| SCHEMBL6004765 | 0.83 | FGFR2 (0.45) | FGFR2KDRAXLSRCTGFBR1 | |
| SCHEMBL6004812 | 0.82 | FGFR2 (0.44) | FGFR2METKDRAXLSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |