Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | MET | P08581 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | TEK | Q02763 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004278 | 0.90 | KDR (0.49) | KDRMETAURKATEKAURKB | |
| SCHEMBL6002914 | 0.81 | PDGFRB (0.49) | KDRMETTGFBR1SRC | |
| SCHEMBL6004288 | 0.80 | KDR (0.41) | KDRMETAURKATEKAURKB | |
| SCHEMBL6004082 | 0.80 | CBFB (0.37) | KDRMETTGFBR1SRCKMT2A | |
| SCHEMBL6002941 | 0.80 | NPSR1 (0.46) | NPSR1RXFP1KDRMETAURKA | |
| SCHEMBL6004857 | 0.79 | SRC (0.37) | KDRMETTGFBR1SRCKMT2A | |
| SCHEMBL6004758 | 0.78 | MET (0.42) | KDRMETAURKATEKAURKB | |
| SCHEMBL6005260 | 0.77 | MET (0.50) | KDRMETAXLTGFBR1SRC | |
| SCHEMBL6004984 | 0.76 | PDE3B (0.39) | METAXLTGFBR1SRC | |
| SCHEMBL6004207 | 0.76 | CYP1A2 (0.37) | KDRMETAXLTGFBR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |