Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004312 | 0.83 | MRGPRX1 (0.56) | MRGPRX1LMNACRHBPCRHR2HTT | |
| SCHEMBL6004268 | 0.81 | ALDH1A1 (0.58) | MRGPRX1LMNACRHBPCRHR2HTT | |
| SCHEMBL6005337 | 0.77 | ALDH1A1 (0.38) | HTTALDH1A1ADORA2AADORA1MET | |
| SCHEMBL13605215 | 0.72 | LCK (0.49) | LCKCSF1RRETMETPDGFRB | |
| SCHEMBL6004712 | 0.72 | PRNP (0.43) | LMNAHTTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6003009 | 0.72 | MAT2A (0.43) | LMNAALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL6004877 | 0.71 | KDM4E (0.46) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL28261532 | 0.70 | PDE10A (0.59) | LMNAHTTALDH1A1HPGDRAB9A | |
| SCHEMBL6005342 | 0.68 | MET (0.42) | ADORA2AADORA1METPDGFRBPDGFRA | |
| SCHEMBL6004765 | 0.67 | FGFR2 (0.45) | PDGFRBPDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |