Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13605215 | 0.87 | LCK (0.49) | EGFRBRAFCSF1RKDM1APDGFRB | |
| SCHEMBL6003009 | 0.86 | MAT2A (0.43) | KDM4ESMN1; SMN2MEN1KMT2AEGFR | |
| SCHEMBL6004712 | 0.86 | PRNP (0.43) | SMN1; SMN2EGFRCSF1RALDH1A1FLT4 | |
| SCHEMBL6005261 | 0.86 | KDM4E (0.49) | KDM4ESMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL6004736 | 0.80 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1CYP3A4KDR | |
| SCHEMBL6005337 | 0.79 | ALDH1A1 (0.38) | EGFRL3MBTL1KDM1AALDH1A1FLT3 | |
| SCHEMBL6004268 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2KMT2AMAPK1ALDH1A1PDGFRB | |
| SCHEMBL15712199 | 0.74 | EGFR (0.59) | KDM4ESMN1; SMN2MEN1KMT2AEGFR | |
| SCHEMBL3895779 | 0.73 | FGFR2 (0.53) | EGFRPDGFRBKDR | |
| SCHEMBL6004276 | 0.73 | LMNA (0.39) | SMN1; SMN2BRAFALDH1A1PDGFRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |