Wedelolactone

Wedelolactone

SCHEMBL601220

COc1cc(O)c2c(c1)oc(=O)c1c3cc(O)c(O)cc3oc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
RECQL P46063 2/20 1.00
BLM P54132 2/20 1.00
SLC22A2 O15244 1/20 1.00
SLC22A1 O15245 1/20 1.00
EED O75530 1/20 1.00
ALOX5 P09917 1/20 1.00
THRB P10828 1/20 1.00
G6PD P11413 1/20 1.00
CBR1 P16152 1/20 1.00
APEX1 P27695 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
MAOA P21397 6/20 0.55
ACHE P22303 1/20 0.54
MAOB P27338 1/20 0.54
MAPT P10636 4/20 0.53
CYP3A4 P08684 3/20 0.53
KDM4E B2RXH2 3/20 0.53
GAA P10253 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Wedelolactone SCHEMBL30669739 1.00 MEN1 (1.00) MEN1KMT2ARECQLBLMSLC22A2
Wedelolactone SCHEMBL29802384 1.00 MEN1 (1.00) MEN1KMT2ARECQLBLMSLC22A2
SCHEMBL14492102 0.91 MEN1 (0.83) MEN1KMT2ARECQLBLMSLC22A2
SCHEMBL27349604 0.88 MEN1 (0.79) MEN1KMT2ARECQLBLMSLC22A2
Demethylwedelolactone SCHEMBL31146849 0.84 MEN1 (0.72) MEN1KMT2ARECQLBLMSLC22A2
Demethylwedelolactone SCHEMBL3364302 0.84 MEN1 (0.72) MEN1KMT2ARECQLBLMSLC22A2
SCHEMBL30321460 0.83 MEN1 (0.71) MEN1KMT2ARECQLBLMSLC22A2
SCHEMBL30335047 0.83 MEN1 (0.71) MEN1KMT2ARECQLBLMSLC22A2
SCHEMBL30015278 0.80 MGAM (0.74) MEN1KMT2ARECQLBLMSLC22A2
SCHEMBL27857524 0.80 MGAM (0.74) MEN1KMT2ARECQLBLMSLC22A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1536 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122004256-A Plant immunity regulator for preventing jackfruit cracking and use method thereof 海南省农业科学院热带果树研究所 2026-05-12 CN claimed
EP-3346842-B1 STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME NOVONESIS PLANT BIOSOLUTIONS AS (DK) 2026-03-25 EP claimed
EP-3946437-B1 EX VIVO METHODS FOR PRODUCING A T CELL THERAPEUTIC AND RELATED COMPOSITIONS AND METHODS H LEE MOFFITT CANCER CT & RES (US) 2025-11-19 EP claimed
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA PLUTO INC (KR) 2025-10-30 US claimed
CN-120078851-A Traditional Chinese medicine formula with cough relieving and phlegm resolving functions and preparation method and application thereof 戴政德 2025-06-03 CN claimed
US-20250170166-A1 HYALURONIC ACID HYDROGEL FORMULATION COMPRISING PHYTOESTROGEN FOR THE TREATMENT OF VAGINAL ATROPHY AND VAGINAL REJUVENATION AND PRODUCTION METHOD THEREOF VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI (TR) 2025-05-29 US claimed
CN-120037393-A Wedelolactone-loaded exosome and application thereof in preparation of medicines for preventing and treating sepsis 中国人民解放军空军军医大学 2025-05-27 CN claimed
WO-2025049966-A9 METHODS AND COMPOSITIONS FOR INCREASING ROR1 EXPRESSION INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) 2025-04-17 WO claimed
CN-119770504-A Pharmaceutical composition for preventing and treating AD and application thereof 黑龙江中医药大学 2025-04-08 CN claimed
US-20250082652-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2025-03-13 US claimed
CN-1810809-A Coumarether compound and new use of its composition SHANGHAI ANPU BIOLOG SCI TECH (CN) 2006-08-02 CN claimed
CN-1566116-A Process for preparing wedelia lactone and application thereof UNIV BEIJING (CN) 2005-01-19 CN claimed
US-6552071-B2 Wedelolactone and its synthesis for treating neurodegenerative diseases PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2003-04-22 US claimed
EP-1237550-A2 METHODS FOR TREATING CELL DEATH DISEASES AND INFLAMMATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2002-09-11 EP claimed
US-20020049251-A1 Methods for treating cell death diseases and inflammation HARVARD COLLEGE, PRESIDENT AND FELLOWS 2002-04-25 US claimed
WO-2001041709-A2 METHODS FOR TREATING CELL DEATH DISEASES AND INFLAMMATION PRESIDENT AND FELLOWS OF HARWARD COLLEGE (US) 2001-06-14 WO claimed
US-5559146-A REGULATION OF SKIN PIGMENTATION, WEDELOLACTONES SABLON LEWIS E (FR) 1996-09-24 US claimed
EP-0595988-B1 COSMETIC COMPOSITIONS COMPRISING AN EXTRACT OF ECLIPTA ALBA SABLON LOUIS EMMANUEL (FR) 1995-12-27 EP claimed
EP-0595988-A1 COSMETIC COMPOSITIONS COMPRISING AN EXTRACT OF ECLIPTA ALBA. SABLON LOUIS EMMANUEL (FR) 1994-05-11 EP claimed
WO-1993001796-A1 COSMETIC COMPOSITIONS COMPRISING AN EXTRACT OF ECLIPTA ALBA SABLON LOUIS EMMANUEL (FR) 1993-02-04 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA MYOF, ALOX5, MYLK2 MEN1 4605/4885KMT2A 2276/4885RECQL 3344/4885
US-20020049251-A1 Methods for treating cell death diseases and inflammation CASP3, CASP9, CASP2 MEN1 3764/4885KMT2A 4228/4885RECQL 4167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.