Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 7/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613810 | 0.90 | BDKRB2 (0.46) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL6615174 | 0.89 | OPRL1 (0.61) | OPRL1OPRM1OPRD1OPRK1GSK3A | |
| SCHEMBL6612028 | 0.87 | LMNA (0.51) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL6012562 | 0.87 | OPRL1 (0.52) | OPRL1OPRM1OPRD1OPRK1GSK3A | |
| SCHEMBL6613893 | 0.85 | OPRM1 (0.48) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL6610245 | 0.84 | CCR3 (0.51) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL6614791 | 0.84 | OPRM1 (0.42) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL6012726 | 0.84 | CXCR3 (0.59) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL7483160 | 0.83 | CCR5 (0.52) | CCR5 | |
| SCHEMBL6615585 | 0.83 | CCR5 (0.52) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119091-B2 | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-10-10 | — | — | US | disclosed |
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |