Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.50 |
| ▸ | CTSA | P10619 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762502 | 0.82 | BCAT2 (0.56) | MKNK1MKNK2LMNABCAT2CTSA | |
| SCHEMBL4966792 | 0.81 | BCAT2 (0.59) | LMNABCAT2RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL23041012 | 0.80 | MAPT (0.53) | LMNABCAT2MAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL20928284 | 0.80 | SLC6A3 (0.57) | LMNAMAPK1POLBCHEK1ALDH1A1 | |
| SCHEMBL11021677 | 0.77 | PGR (0.50) | LMNAMAPK1POLBPTPRCRAB9A | |
| Ethenzamide SCHEMBL25624 | 0.76 | MAPT (0.68) | LMNAMAPK1L3MBTL1MAPTMEN1 | |
| Ethenzamide SCHEMBL27612766 | 0.76 | MAPT (0.68) | LMNAMAPK1L3MBTL1MAPTMEN1 | |
| SCHEMBL5724135 | 0.75 | PARP1 (0.56) | LMNABCAT2CTSAMAPK1POLB | |
| Ethenzamide SCHEMBL22163775 | 0.75 | MAPT (0.66) | LMNAMAPK1L3MBTL1MAPTMEN1 | |
| Ethenzamide SCHEMBL4379591 | 0.75 | MAPT (0.66) | LMNAMAPK1L3MBTL1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638556-A1 | 2-AMINOBENZOTHIAZOLES AS CB1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000301-A1 | 2-AMINOBENZOTHIAZOLES AS CB1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-06 | — | — | WO | disclosed |