Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015704 | 0.80 | PDE3B (0.51) | PDE3BPDE3ANPSR1CYP2D6CYP2C19 | |
| SCHEMBL6015641 | 0.79 | PDE3B (0.46) | PDE3BPDE3ANPSR1HPGDKMT2A | |
| SCHEMBL6015942 | 0.76 | L3MBTL3 (0.61) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL7646781 | 0.74 | PDE3B (0.47) | PDE3BPDE3ANPSR1CYP2D6CYP2C19 | |
| SCHEMBL7329232 | 0.73 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL6016063 | 0.72 | LTA4H (0.55) | KMT2AHRH3 | |
| SCHEMBL6015872 | 0.72 | LTA4H (0.55) | KMT2AHRH3 | |
| SCHEMBL6015798 | 0.72 | ALDH1A1 (0.56) | HPGDKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3082182 | 0.72 | HRH3 (0.55) | PDE3BPDE3ANPSR1CYP2D6HPGD | |
| SCHEMBL11061345 | 0.71 | PDE3B (0.68) | PDE3BPDE3ACYP2C19HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |