Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015775 | 0.98 | LMNA (0.61) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6015714 | 0.88 | HTR6 (0.58) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6015685 | 0.87 | HTR6 (0.63) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6015640 | 0.87 | BCHE (0.51) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6015944 | 0.87 | BCHE (0.48) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6015736 | 0.86 | ALDH1A1 (0.54) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6016017 | 0.85 | DRD2 (0.49) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6016030 | 0.84 | BCHE (0.49) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL10463380 | 0.76 | LMNA (0.97) | LMNAHTTKDM4EMAPK1JAK2 | |
| SCHEMBL6015923 | 0.75 | KMT2A (0.62) | LMNAHTTCYP2D6SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |