Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | GNRHR | P30968 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | CBFB | Q13951 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372705 | 0.90 | DRD2 (0.44) | DRD2DRD4DRD3GNRHRHTR1A | |
| SCHEMBL3370975 | 0.75 | DRD2 (0.48) | DRD2DRD4DRD3GNRHRHTR1A | |
| SCHEMBL3368854 | 0.73 | NCF1 (0.50) | DRD2DRD4DRD3GNRHRHTR1A | |
| SCHEMBL6517385 | 0.73 | DRD2 (0.38) | DRD2DRD4DRD3GNRHRHTR1A | |
| SCHEMBL3368794 | 0.72 | DRD2 (0.39) | DRD2DRD4DRD3GNRHRHTR1A | |
| SCHEMBL14804182 | 0.68 | L3MBTL1 (0.51) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL12377707 | 0.67 | NQO2 (0.49) | SMN1; SMN2MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL30402813 | 0.67 | ALDH1A1 (0.51) | DRD2DRD4DRD3CBFBPDE5A | |
| SCHEMBL7975003 | 0.66 | SMN1; SMN2 (0.54) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| Benzimidazole SCHEMBL376958 | 0.66 | MMP12 (0.46) | TP53SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636216-A1 | BENZIMIDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004101553-A1 | BENZIMIDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-11-25 | — | — | WO | disclosed |