Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 5/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | FES | P07332 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192274 | 0.95 | NPC1 (0.31) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL4191147 | 0.94 | RAB9A (0.39) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL7704487 | 0.90 | LTA4H (0.36) | LMNALTA4HEPHX2 | |
| SCHEMBL4192472 | 0.86 | NPC1 (0.46) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL4186370 | 0.86 | RAB9A (0.42) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL4192264 | 0.85 | LMNA (0.40) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL4190281 | 0.83 | ALDH1A1 (0.40) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL7704544 | 0.83 | ILK (0.41) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL4185618 | 0.83 | KMT2A (0.42) | NPC1RAB9AALDH1A1LMNACYP1A2 | |
| SCHEMBL4190183 | 0.83 | MAPT (0.40) | NPC1RAB9AALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696909-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | Applied Research Systems ARS Holding N.V. (AN) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005025567-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | disclosed |