Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463083 | 0.81 | ADRA2A (0.43) | ADRA2ACYP3A4MAPK1KMT2AMEN1 | |
| SCHEMBL2852938 | 0.81 | TAAR1 (0.56) | CAPN1ADRA2ACYP3A4MAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL6927140 | 0.79 | ADRA2A (0.44) | ADRA2ACYP3A4MAPK1KMT2AMEN1 | |
| SCHEMBL6953644 | 0.73 | TAAR1 (0.62) | CYP3A4HTR2ATAAR1 | |
| SCHEMBL3414586 | 0.73 | CYP3A4 (0.39) | ADRA2ACYP3A4MAPK1KMT2AMEN1 | |
| SCHEMBL3393678 | 0.72 | PYGL (0.57) | CAPN1TAAR1 | |
| SCHEMBL31420517 | 0.72 | NOS2 (0.39) | CAPN1ADRA2ACYP3A4MAPK1KMT2A | |
| SCHEMBL30572274 | 0.71 | CAPN1 (0.44) | CAPN1CYP3A4LMNAHSD17B10SLC22A12 | |
| SCHEMBL16241904 | 0.71 | GPR17 (0.36) | KMT2AMAPTAKR1B1FFAR4TAAR1 | |
| SCHEMBL1405086 | 0.71 | CYP3A4 (0.43) | CYP3A4MAPK1LMNACYP2C9MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708992-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | Pfizer Limited (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005080324-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |