SCHEMBL60235

SCHEMBL60235

[CH2]NC(=O)Cc1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.65
KMT2A Q03164 3/20 0.65
HDAC8 Q9BY41 1/20 0.65
HDAC6 Q9UBN7 1/20 0.65
EPHX2 P34913 2/20 0.61
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
AKR1B1 P15121 1/20 0.56
ALDH1A1 P00352 4/20 0.55
CNR2 P34972 2/20 0.55
HPGD P15428 2/20 0.53
GAA P10253 2/20 0.53
ATM Q13315 1/20 0.52
LMNA P02545 1/20 0.52
RAB9A P51151 1/20 0.50
CNR1 P21554 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL425873 0.83 HDAC8 (0.61) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL699925 0.81 MEN1 (0.71) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL7107935 0.81 ALDH1A1 (0.77) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL743447 0.80 MEN1 (0.42) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL8313887 0.80 CA2 (0.56) LMNARAB9A
Phenylacetohydroxamic Acid SCHEMBL213873 0.79 HDAC8 (1.00) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL27663467 0.78 MEN1 (0.61) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL9199661 0.78 CES2 (0.42) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL3369337 0.78 GAA (0.63) MEN1KMT2AALDH1A1GAALMNA
SCHEMBL6244676 0.78 LMNA (0.59) MEN1KMT2AALDH1A1CNR2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1533 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11939404-B2 Method for producing cyclized peptide having intramolecular S-S bond AJINOMOTO CO., INC. (JP) 2024-03-26 US claimed
CN-116675731-A Small molecule conjugate of targeted cyclin-dependent kinase 12/13 and application thereof 浙江大学 2023-09-01 CN claimed
EP-3882255-A1 METHOD FOR PRODUCING CYCLIZED PEPTIDE HAVING INTRAMOLECULAR S-S BOND AJINOMOTO CO., INC. (JP) 2021-09-22 EP claimed
US-20210277063-A1 METHOD FOR PRODUCING CYCLIZED PEPTIDE HAVING INTRAMOLECULAR S-S BOND AJINOMOTO CO., INC. (JP) 2021-09-09 US claimed
CN-113039193-A Method for producing cyclized peptide having intramolecular S-S bond 味之素株式会社 2021-06-25 CN claimed
EP-3110828-B1 CONTINUOUS FLOW PEPTIDE SYNTHESIS UNIV SZEGEDI (HU) 2020-12-09 EP claimed
US-10577459-B2 Aliphatic poly(ester)s with thiol pendant groups WISTRAND, Anna (SE) 2020-03-03 US claimed
US-20180305495-A1 ALIPHATIC POLY(ESTER)S WITH THIOL PENDANT GROUPS PAPPALARDO, Daniela (IT) 2018-10-25 US claimed
EP-3362500-A1 ALIPHATIC POLY(ESTER)S WITH THIOL PENDANT GROUPS Novus Scientific AB (SE) 2018-08-22 EP claimed
EP-2800756-B1 PEPTIDE C ALPHA-AMIDES, METHODS FOR PREPARING SAME AND USES THEREOF AS PRECURSORS OF PEPTIDE C ALPHA-THIOESTERS FOR PROTEIN SYNTHESIS CENTRE NAT RECH SCIENT (FR) 2018-04-25 EP claimed
CN-1034663-C Method for preparing blood regulation peptide SMITHKLINE BEECHAM CORP (US) 1997-04-23 CN claimed
EP-0621788-A4 HEMOREGULATORY PEPTIDES. SMITHKLINE BEECHAM CORP (US) 1997-03-05 EP claimed
EP-0671931-A4 HEMOREGULATORY PEPTIDES. SMITHKLINE BEECHAM CORP (US) 1995-11-22 EP claimed
EP-0671931-A1 HEMOREGULATORY PEPTIDES SMITHKLINE BEECHAM CORPORATION (US) 1995-09-20 EP claimed
EP-0621788-A1 HEMOREGULATORY PEPTIDES SMITHKLINE BEECHAM CORPORATION (US) 1994-11-02 EP claimed
EP-0408371-B1 Hemoregulatory peptides SMITHKLINE BEECHAM CORP (US) 1994-09-28 EP claimed
WO-1993013789-A1 HEMOREGULATORY PEPTIDES SMITHKLINE BEECHAM CORPORATION (US) 1993-07-22 WO claimed
WO-1993010807-A1 HEMOREGULATORY PEPTIDES SMITHKLINE BEECHAM CORPORATION (US) 1993-06-10 WO claimed
CN-1054773-A HEMOREGULATORY PEPTIDES SMITHKLINE BEECHAM CORP (US) 1991-09-25 CN claimed
EP-0408371-A1 Hemoregulatory peptides SMITHKLINE BEECHAM CORPORATION (US) 1991-01-16 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11939404-B2 Method for producing cyclized peptide having intramolecular S-S bond SPPL2B, PTMS, VIP MEN1 844/4885KMT2A 4316/4885HDAC8 4004/4885
US-10577459-B2 Aliphatic poly(ester)s with thiol pendant groups PARG, TST, CBS MEN1 3136/4885KMT2A 2225/4885HDAC8 2791/4885
US-20210277063-A1 METHOD FOR PRODUCING CYCLIZED PEPTIDE HAVING INTRAMOLECULAR S-S BOND SPPL2B, PTMS, VIP MEN1 844/4885KMT2A 4316/4885HDAC8 4004/4885
US-20180305495-A1 ALIPHATIC POLY(ESTER)S WITH THIOL PENDANT GROUPS PARG, TST, CBS MEN1 3136/4885KMT2A 2225/4885HDAC8 2791/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.