Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783287 | 0.79 | MMP8 (0.55) | L3MBTL1LMNATDP1MMP8 | |
| SCHEMBL6692434 | 0.78 | HTR1A (0.53) | L3MBTL1LMNATDP1MAPTMAPK1 | |
| SCHEMBL11130633 | 0.77 | ABCB1 (0.49) | L3MBTL1LMNATDP1MAPTHTT | |
| SCHEMBL28454623 | 0.76 | L3MBTL1 (0.50) | L3MBTL1LMNATDP1MAPTMAPK1 | |
| SCHEMBL10647194 | 0.75 | MTNR1A (0.55) | L3MBTL1LMNATDP1MAPK1HTR1A | |
| SCHEMBL3420132 | 0.75 | ALDH1A1 (0.66) | L3MBTL1LMNATDP1MAPTMAPK1 | |
| SCHEMBL28473178 | 0.75 | MME (0.47) | L3MBTL1LMNATDP1MAPTMAPK1 | |
| SCHEMBL30011427 | 0.75 | MME (0.47) | L3MBTL1LMNATDP1MAPTMAPK1 | |
| SCHEMBL10758587 | 0.75 | HTR1A (0.56) | GAABRD4HTR1ADRD2PTGER1 | |
| SCHEMBL27541825 | 0.74 | PPARA (0.50) | L3MBTL1LMNATDP1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723121-A1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | Bayer HealthCare AG (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082864-A1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-09-09 | — | — | WO | disclosed |